Intensive care medicine

Adverse effect

Biology

Materials science

Drug resistance

Cancer chemotherapy

Bioavailability

Drug

Drug delivery

Therapeutic index

Nanotechnology

Microbiology

Internal medicine

Pharmacology

Chemotherapy

Medicine

Cancer drugs

Cancer

Signal Transduction and Targeted Therapy

Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

Controlled drug delivery vehicles for cancer treatment and their performance