Signal Transduction and Targeted Therapy
Papers 772
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#1Ajaz A. BhatH-Index: 17
#2Parvaiz Yousuf (Central University of Kashmir)H-Index: 1
Last. Surinder K. Batra (UNMC: University of Nebraska Medical Center)H-Index: 97
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#1Chen Hua (Fudan University)H-Index: 7
#2Qinhai Ma (Guangzhou Medical University)
Last. Zifeng Yang (Guangzhou Medical University)H-Index: 20
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#1Yu-Wen Zhou (Sichuan University)H-Index: 2
#2Yao Xie (Sichuan University)H-Index: 2
Last. Xuelei Ma (Sichuan University)H-Index: 26
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Owing to the limitations of the present efforts on drug discovery against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the biological regulation mechanisms underlying COVID-19, alternative or novel therapeutic targets for COVID-19 treatment are still urgently required. SARS-CoV-2 infection and immunity dysfunction are the two main courses driving the pathogenesis of COVID-19. Both the virus and host factors are potential targets for antiviral ...
#1Chunhui Cai (Tongji University)H-Index: 1
#2Xinyu Hu (Tongji University)H-Index: 3
Last. Zhengliang Gao (Tongji University)H-Index: 13
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#1Zirui Meng (Sichuan University)H-Index: 2
#2Shuo Guo (Sichuan University)H-Index: 2
Last. Binwu Ying (Sichuan University)H-Index: 16
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The worldwide pandemic of coronavirus disease 2019 (COVID-19) presents us with a serious public health crisis. To combat the virus and slow its spread, wider testing is essential. There is a need for more sensitive, specific, and convenient detection methods of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Advanced detection can greatly improve the ability and accuracy of the clinical diagnosis of COVID-19, which is conducive to the early suitable treatment and supports preci...
#1Zhihui Zhang (Peking Union Medical College)H-Index: 4
#2Nan Sun (Peking Union Medical College)H-Index: 17
Last. Jie He (Peking Union Medical College)H-Index: 54
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#1Mei Feng (Fudan University)H-Index: 1
#2Zhongen Wu (Fudan University)
Last. Huiyu Li (Fudan University)
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To date, the overall response rate of PD-1 blockade remains unsatisfactory, partially due to limited understanding of tumor immune microenvironment (TIME). B-cell lymphoma 9 (BCL9), a key transcription co-activator of the Wnt pathway, is highly expressed in cancers. By genetic depletion and pharmacological inhibition of BCL9 in tumors, we found that BCL9 suppression reduced tumor growth, promoted CD8+ T cell tumor infiltration, and enhanced response to anti-PD-1 treatment in mouse colon cancer m...
#1Ying Xu (Fudan University)
#2Guan-Hua Su (Fudan University)
Last. Yi Zhou Jiang (Fudan University)H-Index: 20
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Immunotherapies play critical roles in cancer treatment. However, given that only a few patients respond to immune checkpoint blockades and other immunotherapeutic strategies, more novel technologies are needed to decipher the complicated interplay between tumor cells and the components of the tumor immune microenvironment (TIME). Tumor immunomics refers to the integrated study of the TIME using immunogenomics, immunoproteomics, immune-bioinformatics, and other multi-omics data reflecting the im...
#1Julian Roos (University of Ulm)H-Index: 6
#2Julia Zinngrebe (University of Ulm)H-Index: 3
Last. Pamela Fischer-Posovszky (University of Ulm)H-Index: 31
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#1Maiwen Caudron-Herger (DKFZ: German Cancer Research Center)H-Index: 14
#2Sven Diederichs (DKFZ: German Cancer Research Center)H-Index: 46
Top fields of study
Cancer research
Diabetes mellitus
Cell biology