Original paper
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Abstract
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient–derived organoid (PDO) library that recapitulates the mutational spectrum and transcriptional subtypes of primary pancreatic cancer. New driver oncogenes were nominated and transcriptomic analyses revealed unique clusters. PDOs exhibited...
Paper Details
Title
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Published Date
Sep 1, 2018
Journal
Volume
8
Issue
9
Pages
1112 - 1129
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Notes
History