Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma

Volume: 128, Issue: 7, Pages: 2877 - 2893
Published: Jun 4, 2018
Abstract
Drug resistance remains the key problem in cancer treatment. It is now accepted that each myeloma patient harbors multiple subclones and subclone dominance may change over time. The coexistence of multiple subclones with high or low chromosomal instability (CIN) signature causes heterogeneity and drug resistance with consequent disease relapse. In this study, using a tandem affinity purification-mass spectrometry (TAP-MS) technique, we found...
Paper Details
Title
Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma
Published Date
Jun 4, 2018
Volume
128
Issue
7
Pages
2877 - 2893
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