Pyrimidine metabolism

Antifungal

Antifungal drug

Purine

Conidium

Biology

Antifungal drugs

Dihydroorotate dehydrogenase

Growth inhibition

Cell growth

Lysis

Biochemistry

Botany

Aspergillosis

Drug

Hypha

Immunology

Aspergillus fumigatus

Fungi imperfecti

Microbiology

Enzyme

Pharmacology

Medicine

Chemistry

Cell

Viability assay

Aspergillus

Antiparasitic

Pathology

Antimicrobial Agents and Chemotherapy

F901318 (olorofim) is a novel antifungal drug that is highly active against Aspergillus species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway.

Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus