mitochondria

targets

mars

synthetic

similarity

multicore

urinary sodium

scale-up

organic reactions

mcrs

hypertonic saline

mechanochemical

fragment

calorific value

felsic

people intellectual

smoking_46899

multicomponent reactions

Science

Understanding the practical limitations of chemical reactions is critically important for efficiently planning the synthesis of compounds in pharmaceutical, agrochemical, and specialty chemical research and development. However, literature reports of the scope of new reactions are often cursory and biased toward successful results, severely limiting the ability to predict reaction outcomes for untested substrates. We herein illustrate strategies for carrying out large-scale surveys of chemical reactivity by using a material-sparing nanomole-scale automated synthesis platform with greatly expanded synthetic scope combined with ultrahigh-throughput matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS).

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS