A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

Volume: 9, Issue: 1
Published: May 16, 2018
Abstract
Complementing enzymes in their native environment with either homogeneous or heterogeneous catalysts is challenging due to the sea of functionalities present within a cell. To supplement these efforts, artificial metalloenzymes are drawing attention as they combine attractive features of both homogeneous catalysts and enzymes. Herein we show that such hybrid catalysts consisting of a metal cofactor, a cell-penetrating module, and a protein...
Paper Details
Title
A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
Published Date
May 16, 2018
Volume
9
Issue
1
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