Review paper

Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space

Volume: 44, Pages: 23 - 29
Published: Jun 1, 2018
Abstract
Recent years have seen a dramatic increase in the number of drugs approved in chemical space outside of Lipinski’s rule of 5, that is in what has been termed beyond rule of 5 (bRo5) space. The development of three major classes of oral drugs that treat HIV and HCV infections and the growing evidence that novel, difficult targets can be accessed has prompted research into understanding design of drugs displaying cell permeability, solubility and...
Paper Details
Title
Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space
Published Date
Jun 1, 2018
Volume
44
Pages
23 - 29
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