A compilation of foraminiferal stable isotope measurements from southern high latitude (SHL) deep-sea sites provides a novel perspective important for understanding Earth's paleotemperature and paleoceanographic changes across the rise and fall of the Cretaceous Hot Greenhouse climate and the subsequent Paleogene climatic optimum. Both new and previously published results are placed within an improved chronostratigraphic framework for southern South Atlantic and southern Indian Ocean sites. Sites studied were located between 58° and 65°S paleolatitude and were deposited at middle to upper bathyal paleodepths. Oxygen isotope records suggest similar trends in both bottom and surface water temperatures in the southern sectors of the South Atlantic and in the Indian Ocean basins. Warm conditions were present throughout the Albian , extreme warmth existed during the Cretaceous Thermal Maximum (early-mid-Turonian) through late Santonian , and long-term cooling began in the Campanian and culminated in Cretaceous temperature minima during the Maastrichtian . Gradients between surface and seafloor δ 18 O and δ 13 C values were unusually high throughout the 11.5 m.y. of extreme warmth during the Turonian-early Campanian, but these vertical gradients nearly disappeared by the early Maastrichtian. In absolute terms, paleotemperature estimates that use standard assumptions for pre-glacial seawater suggest sub-Antarctic bottom waters were ≥21 °C and sub-Antarctic surface waters were ≥27 °C during the Turonian , values warmer than published climate models support. Alternatively, estimated temperatures can be reduced to the upper limits of model results through freshening of high latitude waters but only if there were enhanced precipitation of water with quite low δ 18 O values. Regardless, Turonian planktonic δ 18 O values are ~1.5‰ lower than minimum values reported for the Paleocene-Eocene Thermal Maximum (PETM) from the same region, a difference which corresponds to Turonian surface temperatures ~6 °C warmer than peak PETM t...