Baseline NAWM structural integrity and CBF predict periventricular WMH expansion over time

Objective

We aimed to describe and compare baseline cerebral blood flow (CBF) and microstructural characteristics of normal-appearing white matter (NAWM) within the vulnerable periventricular white matter hyperintensity (PVWMH) penumbra region in predicting white matter hyperintensity (WMH) growth over time.

Methods

Fifty-two patients, aged 82.8 years, underwent serial brain MRI, including pulsed arterial spin labeling and...