Reality of the emetogenic level of irinotecan.

Published on Apr 21, 2018in Supportive Care in Cancer3.603
· DOI :10.1007/S00520-018-4196-Z
Maria-Angeles Garcia-del-Barrio1
Estimated H-index: 1
(University of Navarra),
Salvador Martin-Algarra30
Estimated H-index: 30
(University of Navarra),
Azucena Aldaz Pastor1
Estimated H-index: 1
(University of Navarra)
Source
Abstract
Purpose To assess the emetogenic potential of different chemotherapy (CT) regimens in daily clinical practice in an outpatient setting. To optimize antiemetic prophylaxis if necessary
References23
Newest
#1Michael Berger (OSU: Ohio State University)H-Index: 12
#2David S. Ettinger (Johns Hopkins University)H-Index: 77
Last. Miranda Hughes (National Comprehensive Cancer Network)H-Index: 26
view all 29 authors...
: The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Antiemesis address all aspects of management for chemotherapy-induced nausea and vomiting. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines for Antiemesis, specifically those regarding carboplatin, granisetron, and olanzapine.
Source
#1G. Dranitsaris (Ottawa Hospital)H-Index: 1
#2Alex Molassiotis (PolyU: Hong Kong Polytechnic University)H-Index: 73
Last. Matti AaproH-Index: 84
view all 9 authors...
Background: Despite the availability of effective antiemetics and evidence-based guidelines, up to 40% of cancer patients receiving chemotherapy fail to achieve complete nausea and vomiting control. In addition to type of chemotherapy, several patient-related risk factors for chemotherapy-induced nausea and vomiting (CINV) have been identified. To incorporate these factors into the optimal selection of prophylactic antiemetics, a repeated measures cycle-based model to predict the risk of ≥ grade...
Source
#1Karin Jordan (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 33
#2Alexandre Chan (NUS: National University of Singapore)H-Index: 35
Last. Paul J. Hesketh (Lahey Hospital & Medical Center)H-Index: 59
view all 7 authors...
Purpose Employing the same framework as in previous guideline updates, antineoplastic agents were classified into four emetic risk categories. The classification of the emetogenic level of new antineoplastic agents, especially for the oral drugs, represents an increasing challenge. Accurate reporting of emetogenicity of new antineoplastic agents in the absence of preventive antiemetic treatment is rarely available.
Source
#1George DranitsarisH-Index: 24
#2A. MolasiotisH-Index: 1
Last. Matti AaproH-Index: 84
view all 9 authors...
Source
#1Karin Jordan (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 33
#2Franziska Jahn (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 14
Last. Matti AaproH-Index: 84
view all 3 authors...
Abstract The prevention of chemotherapy-induced nausea and vomiting (CINV) has been revolutionized over the past 25 years. Guideline-based treatment means that vomiting can be prevented in the majority, but not in all patients. Therefore, antiemetic research continues with the goal of optimizing CINV control for all patients. This comprehensive review summarizes the research efforts in this field over the past few years. Emerging from this research are two new antiemetic agents, netupitant/palon...
Source
Source
#1Alex Molassiotis (PolyU: Hong Kong Polytechnic University)H-Index: 73
#2Z. Stamataki (University of Manchester)H-Index: 9
Last. Evangelos Kontopantelis (University of Manchester)H-Index: 57
view all 3 authors...
Background A number of risk factors have been implicated in the development of chemotherapy-induced nausea/vomiting (CINV). Our aim was to develop a risk prediction model and identify patients at high risk for developing CINV before their chemotherapy treatment.
Source
#1Ethan Basch (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 82
#2Paul J. HeskethH-Index: 59
Last. Gary H. LymanH-Index: 115
view all 6 authors...
Purpose To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology. Methods A systematic review of the medical literature was completed to inform this update. MEDLINE, the Cochrane Collaboration Library, and meeting materials from ASCO and the Multinational Association for Supportive Care in Cancer were all searched. Primary outcomes of interest were complete response and rates of any vomiting or nausea. Results Thirty-seven trials met prespecified inclusion...
Source
#1Paul J. Hesketh (Lahey Hospital & Medical Center)H-Index: 59
#2Mark G. Kris (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 141
Last. Stacie B. Dusetzina (University of Texas MD Anderson Cancer Center)H-Index: 29
view all 17 authors...
PurposeTo update the ASCO guideline for antiemetics in oncology.MethodsASCO convened an Expert Panel and conducted a systematic review of the medical literature for the period of November 2009 to June 2016.ResultsForty-one publications were included in this systematic review. A phase III randomized controlled trial demonstrated that adding olanzapine to antiemetic prophylaxis reduces the likelihood of nausea among adult patients who are treated with high emetic risk antineoplastic agents. Random...
Source
Antiemetic drug development can follow the same logical path as antineoplastic drug development from appropriate preclinical models through Phase I, Phase II, and Phase III testing. However, due to the marked success of antiemetic therapy over the last 25 years, placebo antiemetic treatment against highly or moderately emetogenic chemotherapy is not acceptable. Promising antiemetic agents therefore rapidly reach Phase III testing, where they are substituted into or added to effective and accepte...
Source
Cited By1
Newest
#1Yuan Chen (Huizhou University)
#2Hong-Wei Li (Huizhou University)
view all 4 authors...
Abstract null null There are currently no vaccines or effective drugs to prevent the disorders caused by avian leukosis virus subgroup J (ALV-J). Hence, it is critical to identify potential biomarkers in ALV-J-infected chickens to prevent ALV-J-induced disorders. We hypothesized that ALV-J infection alters metabolic profile in chickens. In the present study, a nontargeted metabolomics approach based on liquid chromatography coupled with mass spectrometry (LC-MS) was used to find differential met...
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