Adhesion capabilities of various skin architectures found in nature can generate remarkable physical interactions with their engaged surfaces. Among them, octopus suckers have unique hierarchical structures for reversible adhesion in dry and wet conditions. Here, highly adaptable, biocompatible, and repeatable adhesive patches with unfoldable, 3D microtips in micropillars inspired by the rim and infundibulum of octopus suction cup are presented. The bioinspired synthetic adhesives are fabricated by controlling the meniscus of a liquid precursor in a simple molding process without any hierarchical assemblies or additional surface treatments. Experimental and theoretical studies are investigated upon to increase the effective contact area between unfoldable microtips of devices, and enhance adhesion performances and adaptability on a Si wafer in both dry and underwater conditions (max. 11 N cm<sup>-2</sup> in pull-off strength) as well as on a moist pigskin (max. 14.6 mJ peeling energy). Moreover, the geometry-controlled microsuckers exhibit high-repeatability (over 100 cycles) in a pull-off direction. The adhesive demonstrates stable attachments on a moist, hairy, and rough skin, without any observable chemical residues.