Placentation

Cell biology

Biology

Cell culture

Cell growth

Fetus

Biochemistry

Genetics

Placenta

Xenobiotic

Enzyme

Trophoblast

Andrology

Medicine

Pregnancy

Drug and Chemical Toxicology

Our aim was to investigate the effect of some xenobiotics on placentation-related processes in an extravillous trophoblastic cell line (HTR-8/SVneo cells). Amphetamine, MDMA, theophylline, and fluoxetine, but not nicotine, cocaine, and caffeine, had a negative effect on cell proliferation rates, culture growth, viability, or migratory capacity. These compounds have a detrimental effect in placentation-related processes of HTR-8/SVneo cells.

Placentation-related processes in a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) are affected by several xenobiotics