Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Abstract
H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that must be reprogrammed after fertilization. However, the molecular details of these events are lacking in early embryos. Here, we map the genome-wide distribution of H3K9me3 modifications in mouse early embryos. We find that H3K9me3 exhibits distinct dynamic features in promoters and long terminal repeats (LTRs). Both parental genomes undergo large-scale H3K9me3...
Paper Details
Title
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Published Date
Apr 23, 2018
Journal
Volume
20
Issue
5
Pages
620 - 631
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