Biosensing Technologies for Medical Applications, Manufacturing, and Regenerative Medicine

Published on Apr 21, 2018in Stem cell reports6.032
· DOI :10.1007/S40778-018-0123-Y
Ashkan Shafiee12
Estimated H-index: 12
(Wake Forest Institute for Regenerative Medicine),
Elham Ghadiri10
Estimated H-index: 10
(Duke University)
+ 2 AuthorsAnthony Atala140
Estimated H-index: 140
(Wake Forest Institute for Regenerative Medicine)
Sources
Abstract
Purpose of Review The review covers biosensing technologies, their impact on healthcare, and future applications.
📖 Papers frequently viewed together
17 Citations
2010
15 Citations
2009
17 Citations
References94
Newest
#1Indu Sarangadharan (NTHU: National Tsing Hua University)H-Index: 10
#2Abiral Regmi (NTHU: National Tsing Hua University)H-Index: 4
Last. Yu-Lin Wang (NTHU: National Tsing Hua University)H-Index: 22
view all 11 authors...
Abstract In this study, we report the development of a high sensitivity assay for the detection of cardiac troponin I using electrical double layer gated high field AlGaN/GaN HEMT biosensor. The unique gating mechanism overcomes the drawback of charge screening seen in traditional FET based biosensors, allowing detection of target proteins in physiological solutions without sample processing steps. Troponin I specific antibody and aptamer are used as receptors. The tests carried out using purifi...
83 CitationsSource
#1Anuradha Soni (AIIMS: All India Institute of Medical Sciences)H-Index: 3
#2Sandeep Kumar Jha (AIIMS: All India Institute of Medical Sciences)H-Index: 17
Abstract The present work deals with the development of a non-invasive optical glucose biosensor using saliva samples and a smartphone. The sensor was fabricated with a simple methodology by immobilization of Glucose oxidase enzyme along with a pH responsive dye on a filter paper based strip. The strip changes color upon reaction with glucose present in saliva and the color changes were detected using a smartphone camera through RGB profiling. This standalone biosensor showed good sensitivity an...
54 CitationsSource
#1Ashkan Shafiee (Wake Forest Institute for Regenerative Medicine)H-Index: 12
#2Cyrille Norotte (MU: University of Missouri)H-Index: 6
Last. Elham Ghadiri (Duke University)H-Index: 10
view all 3 authors...
Abstract Bioprinting provides an exceptional platform for tissue engineers to deposit cells onto substrates with precision, and to construct three-dimensional (3D) biological structures such as tissues and organs. In extrusion bioprinting of cells, cellular bioink particles in the form of multicellular systems are printed on supportive materials such as agarose. Post-printing and before implantation, the 3D biological structure undergoes a complex maturation process governed by both biological a...
16 CitationsSource
#1Zhaoxin Geng (MUC: Minzu University of China)H-Index: 10
#2Xiong Zhang (MUC: Minzu University of China)H-Index: 2
Last. Hongda Chen (CAS: Chinese Academy of Sciences)H-Index: 25
view all 5 authors...
Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime is an obstacle to extend application in trace biomolecules of cancer antibody or antigen. Here, to overcome water absorption and enhance the THz biosensing sensitivity, two kinds of THz metamaterials ...
72 CitationsSource
#1Congcong Shen (CSU: Central South University)H-Index: 12
#2Ke Zeng (CSU: Central South University)H-Index: 15
Last. Avraham Rasooly (NIH: National Institutes of Health)H-Index: 44
view all 6 authors...
We have developed a new DNA self-assembly amplification technology that generates electric current for electrochemical biosensing. The new technology was used for detection of human epidermal growth factor receptor 2 (HER2). In our technology, an aptamer was utilized both as a ligand for recognition and as a signal generating reporter. The aptasensor is based on a sandwich format and a DNA primer on a HER2 aptamer initiates auxiliary DNA self-assembled on the electrode to form a long one-dimensi...
44 CitationsSource
#1Yantao Chen (UWM: University of Wisconsin–Milwaukee)H-Index: 12
#2Ren Ren (UWM: University of Wisconsin–Milwaukee)H-Index: 15
Last. Junhong Chen (UWM: University of Wisconsin–Milwaukee)H-Index: 86
view all 9 authors...
The Ebola virus transmits a highly contagious, frequently fatal human disease for which there is no specific antiviral treatment. Therefore, rapid, accurate, and early diagnosis of Ebola virus disease (EVD) is critical to public health containment efforts, particularly in developing countries where resources are few and EVD is endemic. We have developed a reduced graphene oxide-based field-effect transistor method for real-time detection of the Ebola virus antigen. This method uses the attractiv...
61 CitationsSource
#1Javad Tavakoli (Flinders University)H-Index: 15
#2Youhong Tang (Flinders University)H-Index: 40
Biosensors that detect and convert biological reactions to a measurable signal have gained much attention in recent years. Between 1950 and 2017, more than 150,000 papers have been published addressing the applications of biosensors in different industries, but to the best of our knowledge and through careful screening, critical reviews that describe hydrogel based biosensors for biomedical applications are rare. This review discusses the biomedical application of hydrogel based biosensors, base...
156 CitationsSource
#1Xin Yi (SCUT: South China University of Technology)H-Index: 5
#2Yuxuan Wu (SYSU: Sun Yat-sen University)H-Index: 4
Last. Chengyun Ning (SCUT: South China University of Technology)H-Index: 28
view all 10 authors...
Traced dopamine (DA) detection is critical for the early diagnosis and prevention of some diseases such as Parkinson’s, Alzheimer and schizophrenia. In this research, a novel self-supporting three dimensional (3D) bicontinuous nanoporous electrochemical biosensor was developed for the detection of dopamine by Differential Pulse Voltammetry (DPV). This biosensor was fabricated by electrodepositing palladium nanoparticles (Pd) onto self-supporting nanoporous gold (NPG) wire. Because of the synergi...
22 CitationsSource
#1Yong Qing Fu (Northumbria University)H-Index: 65
#2Jack Luo (University of Bolton)H-Index: 2
Last. William I. Milne (University of Cambridge)H-Index: 90
view all 12 authors...
The authors acknowledge support from the Innovative electronic Manufacturing Research Centre (IeMRC) through the EPSRC funded flagship project SMART MICROSYSTEMS (FS/01/02/10), Knowledge Transfer Partnership No KTP010548, EPSRC project EP/L026899/1, EP/F063865/1; EP/F06294X/1, EP/P018998/1, the Royal Society-Research Grant (RG090609) and Newton Mobility Grant (IE161019) through Royal Society and NFSC, the Scottish Sensing Systems Centre (S3C), Royal Society of Edinburgh, Carnegie Trust Funding, ...
246 CitationsSource
#1Anshu Thapa (USP: University of São Paulo)H-Index: 1
#2Andrey Soares (USP: University of São Paulo)H-Index: 10
Last. Osvaldo N. Oliveira (USP: University of São Paulo)H-Index: 69
view all 9 authors...
Biosensors fabricated with nanomaterials promise faster, cheaper, and more efficient alternatives to traditional, often bulky devices for early cancer diagnosis. In this study, we fabricated a thin film sensing unit on interdigitated gold electrodes combining polyethyleneimine and carbon nanotubes in a layer by layer fashion, onto which antibodies anti-CA19-9 were adsorbed with a supporting layer of N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide solution. By use of impeda...
36 CitationsSource
Cited By14
Newest
#1Mario Rothbauer (Medical University of Vienna)H-Index: 15
#2Barbara Bachmann (TU Wien: Vienna University of Technology)H-Index: 7
Last. Peter Ertl (TU Wien: Vienna University of Technology)H-Index: 23
view all 7 authors...
Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development, improve the clinical translation of basic research, and provide personalized intervention strategies. In the last decade, big pharma has engaged in many academic research cooperations to develop organ-on-a-chip systems for future drug discoveries. Although most organ-on-a-chip systems present proof-of-concept studies, miniaturized organ systems still need to demonstrate translational relevance and predict...
2 CitationsSource
#1Keshav Narayan Alagarsamy (UM: University of Manitoba)H-Index: 2
#2Sajitha Mathan (SASTRA: Shanmugha Arts, Science, Technology & Research Academy)H-Index: 1
Last. Sanjiv Dhingra (UM: University of Manitoba)H-Index: 22
view all 7 authors...
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to "damage-control" rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family ...
5 CitationsSource
#1Ashkan Shafiee (Wake Forest Institute for Regenerative Medicine)H-Index: 12
#2Elham Ghadiri (Wake Forest Institute for Regenerative Medicine)H-Index: 10
Last. Anthony Atala (Wake Forest Institute for Regenerative Medicine)H-Index: 140
view all 3 authors...
Source
#1Iswary Letchumanan (UniMAP: Universiti Malaysia Perlis)H-Index: 4
#2M. K. Md Arshad (UniMAP: Universiti Malaysia Perlis)H-Index: 24
Last. S.R. Balakrishnan (USIM: Universiti Sains Islam Malaysia)H-Index: 3
view all 5 authors...
Field of generating a surface thin film is emerging broadly in sensing applications to obtain the quick and fast results by forming the high-performance sensors. Incorporation of thin film technologies in sensor development for the better sensing could be a promising way to attain the current requirements. This work predominantly delineates the fabrication of the dielectric sensor using two different sensing materials (Gold and Aluminium). Conventional photolithography was carried out using sili...
13 CitationsSource
#1Liping Xie (NU: Northeastern University)H-Index: 11
#2Hedele Zeng (NU: Northeastern University)H-Index: 2
Last. Wei Qian (University of Texas at Austin)H-Index: 60
view all 4 authors...
Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, c...
24 CitationsSource
#1Ashkan Shafiee (Wake Forest Institute for Regenerative Medicine)H-Index: 12
#2Elham Ghadiri (Wake Forest Institute for Regenerative Medicine)H-Index: 10
Last. Anthony Atala (Wake Forest Institute for Regenerative Medicine)H-Index: 140
view all 5 authors...
Over the past ten years, tissue engineering has witnessed significant technological and scientific advancements. Progress in both stem cell science and additive manufacturing have established new horizons in research and are poised to bring improvements in healthcare closer to reality. However, more sophisticated indications such as the scale-up fabrication of biological structures (e.g., human tissues and organs) still require standardization. To that end, biocompatible electronics may be helpf...
5 CitationsSource
#1Rebecca Peters (UM: University of Miami)
#2Mario Stevenson (UM: University of Miami)H-Index: 52
Abstract Zika virus (ZIKV) captured mass public attention in 2014–16 due to its potentially devastating teratogenic effects in unborn babies. Although recent years show a decline in disease activity as ZIKV settles into endemic New World cycles, the significant challenges that originally complicated its diagnosis remain, and linkages to foetal microcephaly make safe, accurate, and timely detection especially important. The present chapter seeks to define current direct and indirect immunological...
Source
#1Jaison JeevanandamH-Index: 13
Last. Michael K. DanquahH-Index: 43
view all 4 authors...
1 CitationsSource
#1Ashkan Shafiee (Wake Forest Institute for Regenerative Medicine)H-Index: 12
#2Elham Ghadiri (Wake Forest Institute for Regenerative Medicine)H-Index: 10
Last. Anthony Atala (Wake Forest Institute for Regenerative Medicine)H-Index: 140
view all 4 authors...
: The number of patients requiring organ transplantations is exponentially increasing. New organs are either provided by healthy or deceased donors, or are grown in laboratories by tissue engineers. Post-surgical follow-up is vital for preventing any complications that can cause organ rejection. Physiological monitoring of a patient who receives newly transplanted organs is crucial. Many efforts are being made to enhance follow-up technologies for monitoring organ recipients, and point-of-care d...
8 CitationsSource
#1Ashkan Shafiee (Wake Forest Institute for Regenerative Medicine)H-Index: 12
#2Elham Ghadiri (Wake Forest Institute for Regenerative Medicine)H-Index: 10
Last. Anthony Atala (Wake Forest Institute for Regenerative Medicine)H-Index: 140
view all 11 authors...
Bioprinters are being extensively used for different applications in life sciences and medicine in general and more specifically in regenerative medicine, tissue, and organ fabrication. The technology has matured from its purely academic origin owing to the involvement of materials science, engineering, biology, and physics, as well as commercial entities. Nevertheless, despite the progress in the science and the understanding of the mechanisms underlying the various bioprinting technologies, fu...
15 CitationsSource