Original paper
Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice
Abstract
Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NEU1-deficient CathAS190A-Neo mice (hypomorph of the NEU1 activator protein, cathepsin A/CathA) on a high-fat diet (HFD) develop hyperglycaemia and insulin...
Paper Details
Title
Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice
Published Date
Apr 21, 2018
Journal
Volume
12
Pages
76 - 88