Gene

Cell biology

SUPERFAMILY

Guanine nucleotide exchange factor

Dynamin

GTPase

Biology

Receptor

Signal transduction

Biochemistry

DOCK

Computational biology

G protein

Endocytosis

Nucleotide

GTP'

Enzyme

GTP-binding protein regulators

Ras superfamily

Current Biology

The dynamin superfamily comprises a growing assortment of multi-domain GTPases, found from bacteria to man, that are distinguished from typical GTPases of the Ras, Rab and G-protein families by their modular structure (Figure 1), relatively large size (>70 kDa), and low affinity for guanine nucleotides. In addition, they display a conserved propensity to self-assemble into polymeric arrays, the dynamics of which are regulated by an autonomous, assembly-stimulated GTPase activity.

The dynamin superfamily