Original paper
Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition
Abstract
Pain, though serving the beneficial function of provoking a response to dangerous situations, is an unpleasant sensory and emotional experience. Transient receptor potential ankyrin 1 (TRPA1) is a member of the transient receptor potential (TRP) cation channel family and is localized in "nociceptors," where it plays a key role in the transduction of chemical, inflammatory, and neuropathic pain. TRPA1 is a Ca2+-permeable, nonselective cation...
Paper Details
Title
Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition
Published Date
Apr 27, 2018
Volume
150
Issue
5
Pages
751 - 762
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Notes
History