Protein–protein interaction

Physics

Peptidomimetic

Biophysics

Function (biology)

Component (thermodynamics)

Nanotechnology

Chemistry

Materials science

Combinatorial chemistry

Peptide

Biochemistry

Computational biology

Biology

Cell biology

Thermodynamics

Molecules

Protein–protein interactions (PPIs) are tremendously important for the function of many biological processes. However, because of the structure of many protein–protein interfaces (flat, featureless and relatively large), they have largely been overlooked as potential drug targets. In this review, we highlight the current tools used to study the molecular recognition of PPIs through the use of different peptidomimetics, from small molecules and scaffolds to peptides. Then, we focus on constrained peptides, and in particular, ways to constrain α-helices through stapling using both one- and two-component techniques.

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions