Review paper
RNA N6-methyladenosine modification in cancers: current status and perspectives
Abstract
N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygotic transition. The m6A modification is deposited by the m6A methyltransferase complex (MTC; i.e., writer) composed of METTL3, METTL14 and WTAP, and...
Paper Details
Title
RNA N6-methyladenosine modification in cancers: current status and perspectives
Published Date
Apr 23, 2018
Journal
Volume
28
Issue
5
Pages
507 - 517
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