Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications
Abstract
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited expression, predominantly on regulatory T cells (Tregs). In addition, the signaling pathway by sTNF via TNFR1 mainly triggers pro-inflammatory pathways, and mTNF binding to TNFR2 usually...
Paper Details
Title
Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications
Published Date
Apr 19, 2018
Journal
Volume
9
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