Original paper
Protective role of the lipid phosphatase Fig4 in the adult nervous system
Abstract
The signaling lipid phosphatidylinositol 3,5-bisphosphate, PI(3,5)P2, functions in vesicular trafficking through the endo-lysosomal compartment. Cellular levels of PI(3,5)P2 are regulated by an enzyme complex comprised of the kinase PIKFYVE, the phosphatase FIG4, and the scaffold protein VAC14. Mutations of human FIG4 cause inherited disorders including Charcot-Marie-Tooth disease type 4J, polymicrogyria with epilepsy, and Yunis-Varón syndrome....
Paper Details
Title
Protective role of the lipid phosphatase Fig4 in the adult nervous system
Published Date
Apr 24, 2018
Journal
Volume
27
Issue
14
Pages
2443 - 2453
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Notes
History