Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease

A failure of protein degradation may underpin Lewy body disease (LBD) where α‐synuclein is assimilated into the pathognomic Lewy bodies and Lewy neurites. We investigated histological alterations in lysosomes and autophagosomes in the substantia nigra (SN) and cingulate gyrus (CG) in 34 patients with LBD employing antibodies against phosphorylated α‐synuclein and lysosomal (lysosomal associated membrane proteins 1 and 2 (LAMP‐1 and LAMP‐2),...