The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis.

Published on Jan 1, 2018in Neuroendocrinology4.271
· DOI :10.1159/000487762
Kirsty A Walters24
Estimated H-index: 24
Melissa C Edwards5
Estimated H-index: 5
+ 4 AuthorsDavid J. Handelsman104
Estimated H-index: 104
The androgen receptor (AR) is expressed throughout the hypothalamic-pituitary-gonadal (HPG) axis, and findings from female global AR knockout mice confirm that AR-mediated androgen actions play important roles in regulating female reproductive function. We generated neuron-specific AR knockout mice (NeurARKO) to investigate the functional role of neuronal AR-mediated androgen action in regulating the female HPG axis and fertility. Relative to control females, NeurARKO females exhibited elevated luteinizing hormone (LH) levels at diestrus ( p p Kiss1 mRNA expression in the anteroventral periventricular nucleus at diestrus ( p p Kiss1 ( p Tac2 , p p p < 0.01). Despite the findings of aberrant neuroendocrine and ovarian characteristics in the NeurARKO females, estrous cyclicity and overall fertility were comparable between NeurARKO and WT females. In conclusion, our findings revealed that selective loss of neuronal AR actions impacts the kisspeptin/GnRH/LH cascade leading to compromised ovarian follicle dynamics.
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