Phenotype

Cell

Progenitor cell

Epithelium

Biology

Gene

Progenitor

Wnt signaling pathway

Myoepithelial cell

Immunohistochemistry

Regeneration (biology)

Cell type

Immunology

Stem cell

Signal transduction

Respiratory epithelium

Cell biology

Genetics

Cell stem cell

Following severe injury to the surface airway epithelium (SAE), Wnt signals activate myoepithelial cells in the submucosal glands (SMGs) to function as reserve stem cells for multipotent basal cells in the SAE and other SMG cell types. Lef-1 activation induces the myoepithelial cell regenerative response and a basal cell-like phenotype.

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium