Biology

Antigen

Decidua

Cytotoxic T cell

Andrology

Immunology

Pregnancy

Genetics

Medicine

IL-2 receptor

Biochemistry

Fetus

In vitro

T cell

Abortion

Immune system

Placenta

FOXP3

BioScience Trends

The aim of the current study was to determine the pattern of immune cells and related functional molecules in peripheral blood and at the maternal-fetal interface in women with unexplained recurrent spontaneous abortion (URSA). In part I, 155 women were included and divided into four groups: non-pregnant controls with no history of URSA (NPCs), pregnant controls with no history of URSA (PCs), non-pregnant women with a history of URSA (NPUs), and pregnant women with a history of URSA (PUs). Venous blood samples were collected and analyzed. In part II, 35 subjects with URSA and 40 subjects in the early stage of normal pregnancy who chose to undergo an abortion were recruited. Samples of the decidua were collected, and the proportion of immune cells and the expression of related molecules were evaluated. Peripheral regulatory T cells (Treg cells) increased in PCs compared to NPCs, but in women with URSA the flux of Treg cells disappeared when pregnancy occurred. Levels of interleukin-10 (IL-10), cytotoxic T lymp...

Distinct pattern of Th17/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion