An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles
Abstract
Microscopic viscosity (microviscosity) is a key determinant of diffusion in the cell and defines the rate of biological processes occurring at the nanoscale, including enzyme-driven metabolism and protein folding. Here we establish a rotor-based organelle viscosity imaging (ROVI) methodology that enables real-time quantitative mapping of cell microviscosity. This approach uses environment-sensitive dyes termed molecular rotors, covalently linked...
Paper Details
Title
An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles
Published Date
Apr 12, 2018
Journal
Volume
12
Issue
5
Pages
4398 - 4407
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