Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia

Volume: 3, Issue: 5, Pages: 600 - 610
Published: Apr 16, 2018
Abstract
Bacterial septicaemia is a major cause of mortality, but its pathogenesis remains poorly understood. In experimental pneumococcal murine intravenous infection, an initial reduction of bacteria in the blood is followed hours later by a fatal septicaemia. These events represent a population bottleneck driven by efficient clearance of pneumococci by splenic macrophages and neutrophils, but as we show in this study, accompanied by occasional...
Paper Details
Title
Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia
Published Date
Apr 16, 2018
Volume
3
Issue
5
Pages
600 - 610
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