Overestimation of cardiac lactate production caused by liver metabolism of hyperpolarized [1‐13C ]pyruvate
Abstract
The purpose of this work was to study the contribution of liver [1-13 C]lactate to the lactate signal detected in the heart following injection of hyperpolarized [1-13 C]pyruvate.A slice-selective saturation scheme was incorporated into a hybrid metabolic imaging and spectroscopy approach to selectively presaturate lactate in the liver. Imaging and slice-selective spectroscopy of [1-13 C]pyruvate and its downstream metabolites were sequentially...
Paper Details
Title
Overestimation of cardiac lactate production caused by liver metabolism of hyperpolarized [1‐13C ]pyruvate
Published Date
Apr 1, 2018
Volume
80
Issue
5
Pages
1882 - 1890
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