On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
Abstract
Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, the mechanism of formation and certain structural features of LNP-siRNA remain obscure. These systems are formed from lipid mixtures (cationic lipid, distearoylphosphatidylcholine, cholesterol, and...
Paper Details
Title
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
Published Date
Apr 3, 2018
Journal
Volume
12
Issue
5
Pages
4787 - 4795
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