Galectins Control mTOR in Response to Endomembrane Damage
Abstract
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to orchestrate autophagic responses is not known. Here we show that mTOR is inhibited by lysosomal damage. Lysosomal damage, recognized by galectins, leads to...
Paper Details
Title
Galectins Control mTOR in Response to Endomembrane Damage
Published Date
Apr 1, 2018
Journal
Volume
70
Issue
1
Pages
120 - 135.e8
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