Small-Format Drug Conjugates: A Viable Alternative to ADCs for Solid Tumours?
Abstract
Antibody-Drug Conjugates (ADCs) have been through multiple cycles of technological innovation since the concept was first practically demonstrated ~40 years ago. Current technology is focusing on large, whole immunoglobulin formats (of which there are approaching 100 in clinical development), many with site-specifically conjugated payloads numbering 2 or 4. Despite the success of trastuzumab-emtansine in breast cancer, ADCs have generally failed...
Paper Details
Title
Small-Format Drug Conjugates: A Viable Alternative to ADCs for Solid Tumours?
Published Date
Mar 31, 2018
Journal
Volume
7
Issue
2
Pages
16 - 16
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History