Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers
Abstract
NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMA) of the lung. The oncoprotein binds ERBB3–ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm of ERBB3/ERBB2 inhibition. As proof of concept, a durable response was achieved with anti-ERBB3 mAb therapy (GSK2849330) in an exceptional responder with an NRG1-rearranged IMA on a phase I trial (NCT01966445). In...
Paper Details
Title
Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers
Published Date
May 31, 2018
Journal
Volume
8
Issue
6
Pages
686 - 695
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