The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

Volume: 87, Issue: 1, Pages: 809 - 837
Published: Jun 20, 2018
Abstract
To maintain an asymmetric distribution of ions across membranes, protein pumps displace ions against their concentration gradient by using chemical energy. Here, we describe a functionally analogous but topologically opposite process that applies to the lipid transfer protein (LTP) oxysterol-binding protein (OSBP). This multidomain protein exchanges cholesterol for the phosphoinositide phosphatidylinositol 4-phosphate [PI(4)P] between two...
Paper Details
Title
The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol
Published Date
Jun 20, 2018
Volume
87
Issue
1
Pages
809 - 837
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