Original paper
The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol
Abstract
To maintain an asymmetric distribution of ions across membranes, protein pumps displace ions against their concentration gradient by using chemical energy. Here, we describe a functionally analogous but topologically opposite process that applies to the lipid transfer protein (LTP) oxysterol-binding protein (OSBP). This multidomain protein exchanges cholesterol for the phosphoinositide phosphatidylinositol 4-phosphate [PI(4)P] between two...
Paper Details
Title
The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol
Published Date
Jun 20, 2018
Volume
87
Issue
1
Pages
809 - 837
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Notes
History