Precast concrete facilitates a construction method using durable and rapidly erectable prefabricated members to create cost-effective and high-quality structures. In this method, the connections between the precast members as well as between the members and the foundation require special attention to ensure good seismic performance. Extensive research conducted since the 1980s has led to new precast concrete structural systems, designs, details, and techniques that are particularly suited for use in regions of high seismic hazard. This paper reviews the state of the art of these advances, including code developments and practical applications, related to four different systems: (1) moment frames; (2) structural walls; (3) floor diaphragms; and (4) bridges. It is concluded from this review that the widespread use of precast concrete in seismic regions is feasible today and that the jointed connection innovation introduced through precast research leads to improved seismic performance of building and bridge structures.