Biomimetic Desymmetrization of a Carboxylic Acid

Volume: 140, Issue: 6, Pages: 1998 - 2001
Published: Feb 5, 2018
Abstract
The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate–catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to...
Paper Details
Title
Biomimetic Desymmetrization of a Carboxylic Acid
Published Date
Feb 5, 2018
Volume
140
Issue
6
Pages
1998 - 2001
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