Roles of pH in control of cell proliferation

Precise spatiotemporal regulation of intracellular pH ( pH i ) is a prerequisite for normal cell function, and changes in pH i or pericellular pH ( pH e ) exert important signalling functions. It is well established that proliferation of mammalian cells is dependent on a permissive pH i in the slightly alkaline range (7.0‐7.2). It is also clear that mitogen signalling in nominal absence of is associated with an intracellular alkalinization (~0.3...