A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer

High expression of glioma-associated oncogene homolog-1 (GLI1) is associated with poor prognosis in estrogen receptor (ER) positive breast cancers. We sought to define a GLI1-dependent gene signature in ER-positive tumors that could further stratify patients at higher risk for disease recurrence and potentially lead to novel combination therapies. We identified an inverse correlation between GLI1 expression and distant disease-free survival...