Original paper
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2
Abstract
Proteins in the fibrous amyloid state are a major hallmark of neurodegenerative disease. Understanding the multiple conformations, or polymorphs, of amyloid proteins at the molecular level is a challenge of amyloid research. Here, we detail the wide range of polymorphs formed by a segment of human TAR DNA-binding protein 43 (TDP-43) as a model for the polymorphic capabilities of pathological amyloid aggregation. Using X-ray diffraction,...
Paper Details
Title
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2
Published Date
Mar 7, 2018
Volume
25
Issue
4
Pages
311 - 319