Kinase

MAPK/ERK pathway

Cell biology

Biology

Interferon

STAT3

Signal transduction

Cancer research

Protein kinase A

stat

Immunology

Immune system

Cytokine

Internal medicine

Cancer therapy

Medicine

Interferon gamma

Tumor necrosis factor alpha

Cancer

Cancer cell

Cell Proliferation

Tumour necrosis factor alpha ( TNF α) and interferon gamma ( IFN γ) were originally found to be produced by inflammatory cells and play important roles in the immune system and surveillance of tumour growth. By activating distinct signalling pathways of nuclear factor‐κB ( NF ‐κB), mitogen‐activated protein kinase ( MAPK ), and JAK / STAT , TNF α and IFN γ were reported to effectively trigger cell death and perform powerful anti‐cancer effects. In this review, we will discuss the new advancements of TNF α and IFN γ in anti‐cancer therapy.

Anti‐cancer therapy with <scp>TNF</scp>α and <scp>IFN</scp>γ: A comprehensive review

Anti‐cancer therapy with TNFα and IFNγ: A comprehensive review