Review paper
Clinical implications of PTEN loss in prostate cancer
Abstract
Genomic aberrations of the PTEN tumour suppressor gene are among the most common in prostate cancer. Inactivation of PTEN by deletion or mutation is identified in ∼20% of primary prostate tumour samples at radical prostatectomy and in as many as 50% of castration-resistant tumours. Loss of phosphatase and tensin homologue (PTEN) function leads to activation of the PI3K-AKT (phosphoinositide 3-kinase-RAC-alpha serine/threonine-protein kinase)...
Paper Details
Title
Clinical implications of PTEN loss in prostate cancer
Published Date
Feb 20, 2018
Journal
Volume
15
Issue
4
Pages
222 - 234
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