Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Abstract
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogenic levels, MYCN associates with E-box binding motifs in an affinity-dependent manner, binding to strong canonical E-boxes at promoters and invading abundant weaker non-canonical E-boxes clustered at...
Paper Details
Title
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Published Date
Jan 29, 2018
Journal
Volume
50
Issue
4
Pages
515 - 523
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