Inflammasome, Inflammation, and Tissue Homeostasis

Tissue homeostasis in the intestine requires the coordinate action between immune effectors, stromal cells and the commensal microbiota. Distinct inflammasome sensors mediate the crosstalk between immune effectors, intestinal epithelial cells, and the microbiota to maintain intestinal homeostasis. The cytokines IL-1β and IL-18 have key functions in the maintenance of homeostatic balance in the intestine. Whether cytokines promote or inhibit...