Internal medicine

Sphingolipid

Biology

Endocrinology

Function (biology)

Cytoplasm

Chemistry

Protein kinase C

Insulin resistance

Subcellular localization

Insulin

Skeletal muscle

Insulin sensitivity

Diacylglycerol kinase

Signal transduction

Mitochondrion

Cell biology

Biochemistry

Medicine

Intracellular

JCI Insight

BACKGROUND. Accumulation of diacylglycerol (DAG) and sphingolipids is thought to promote skeletal muscle insulin resistance by altering cellular signaling specific to their location. However,the subcellular localization of bioactive lipids in human skeletal muscle is largely unknown.

Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle