Review paper
Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention
Abstract
Numerous laboratory and epidemiologic studies strongly implicate endogenous and exogenous estrogens in the etiology of breast cancer. Data summarized herein suggest that the ACI rat model of 17β-estradiol (E2)-induced mammary cancer is unique among rodent models in the extent to which it faithfully reflects the etiology and biology of luminal types of breast cancer, which together constitute ~70% of all breast cancers. E2 drives cancer...
Paper Details
Title
Rat models of 17β-estradiol-induced mammary cancer reveal novel insights into breast cancer etiology and prevention
Published Date
Mar 1, 2018
Journal
Volume
50
Issue
3
Pages
215 - 234
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