Review paper
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
Abstract
Gene‐based therapy is one of essential therapeutic strategies for precision medicine through targeting specific genes in specific cells of target tissues. However, there still exist many problems that need to be solved, such as safety, stability, selectivity, delivery, as well as immunity. Currently, the key challenges of gene‐based therapy for clinical potential applications are the safe and effective nucleic acid drugs as well as their safe...
Paper Details
Title
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
Published Date
Jan 5, 2018
Journal
Volume
38
Issue
3
Pages
829 - 869