SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

Better understanding of how genetic and epigenetic components control beta cell differentiation and function is key to the discovery of novel therapeutic approaches to prevent beta cell dysfunction and failure in the progression of type 2 diabetes. Our goal was to elucidate the role of histone deacetylase sirtuin 6 (SIRT6) in beta cell development and homeostasis.Sirt6 endocrine progenitor cell conditional knockout and beta cell-specific...