SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

Volume: 61, Issue: 4, Pages: 906 - 918
Published: Jan 10, 2018
Abstract
Better understanding of how genetic and epigenetic components control beta cell differentiation and function is key to the discovery of novel therapeutic approaches to prevent beta cell dysfunction and failure in the progression of type 2 diabetes. Our goal was to elucidate the role of histone deacetylase sirtuin 6 (SIRT6) in beta cell development and homeostasis.Sirt6 endocrine progenitor cell conditional knockout and beta cell-specific...
Paper Details
Title
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice
Published Date
Jan 10, 2018
Volume
61
Issue
4
Pages
906 - 918
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.