Original paper
Estimating kinetic mechanisms with prior knowledge I: Linear parameter constraints
Abstract
To understand how ion channels and other proteins function at the molecular and cellular levels, one must decrypt their kinetic mechanisms. Sophisticated algorithms have been developed that can be used to extract kinetic parameters from a variety of experimental data types. However, formulating models that not only explain new data, but are also consistent with existing knowledge, remains a challenge. Here, we present a two-part study describing...
Paper Details
Title
Estimating kinetic mechanisms with prior knowledge I: Linear parameter constraints
Published Date
Jan 10, 2018
Volume
150
Issue
2
Pages
323 - 338
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