Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses

Synaptic remodeling is driven by both activity-dependent and spontaneous processes. The magnitude of spontaneous synaptic remodeling is comparable with that of activity-dependent remodeling. Spontaneous synaptic remodeling processes can give rise to a full repertoire of synaptic sizes even in the complete absence of activity. While spontaneous remodeling processes drive continuous fluctuations in the properties of individual synapses, stable and...