HISP: a hybrid intelligent approach for identifying directed signaling pathways

Signal transduction plays important roles in biological systems. Unfortunately, our knowledge about signaling pathways is far from complete. Specifically, the direction of signaling flows is less known even though the signaling molecules of some signaling pathways have been determined. In this paper, we propose a novel hybrid intelligent method, namely HISP (Hybrid Intelligent approach for identifying directed Signaling Pathways), to determine...